Host-Microbe Core > Investigators
Dionysios Antonopoulos, Ph.D.
Enteric Microbiology Component Director
Phone: 773-702-6458; (630) 252-3925 (Argonne National Lab)
Dr. Dionysios Antonopoulos is a microbiologist interested in studying the formation and development of microbial communities. His interest in understanding mammalian gastrointestinal function has been complemented by ongoing research in environmental systems (subsurface and topsoil systems). Although the scales are vastly different between the two, many of the approaches used in both GI and field research are steeped in classical ecological theory and serve to circumnavigate the complex nature of the microbial communities underlying system function. His group is actively involved in applying second-generation DNA sequencing technologies to describing both the structure and function of microbial communities in these systems and has taken advantage of the computational resources available at Argonne National Laboratory (ANL, http://www.igsb.org/services/hgac/) to handle the scale of data afforded by these technologies. His joint appointment between the University of Chicago (Dept of Medicine) and ANL, via the Institute for Genomics and Systems Biology, enables interactions between the clinical and next generation laboratory approaches (including shotgun metagenomics) to understanding the microbial world.
Alexander Chervonsky, M.D., Ph.D.
Gnotobiotic Mouse Component Director
Dr. Alexander Chervonsky is doing basic research in the areas of intestinal microbial sampling and autoimmunity (Type 1 diabetes, T1D). Dr. Chervonsky was trained at the Jackson Laboratory as a mouse geneticist and has established the germ-free facility at the University of Chicago. He employs methods of gnotobiotic association of the germ-free mice to study the role of different microbes in generation of tolerance to pancreatic antigens in T1D. He also uses this approach to study the bacteria-induced transformation of intestinal epithelium in microbe-sampling cells. He is involved in many collaborative studies with other investigators at the University. His work is supported by grants from the NIH and the Juvenile Diabetes Research Foundation. In addition to his DDRCC duties, Dr. Chervonsky is Chair of Committee on Immunology.